Supplementary Figure S1, S2, S3, S4, S5 and S6. Supplementary Tables S1 and S2. from VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Supplementary Material and Methods. Supplementary Fig. S1. Additional characterization of in vivo chemotherapy treatment of human AML xenotransplanted mice and metabolic characterization of chemotherapy exposed human AML cells. Supplementary Fig. S2. Chemotherapy treated AML cells exhibited enhanced VEGFR- 2 expression. Supplementary Fig. S3. VEGFR-2 signaling regulates mitochondrial homeostasis and oxidative stress in AML. Supplementary Fig. S4. Regulation of PGC-1α by VEGFR-2 signaling underlies the chemotherapy-sensitization provided by VEGFR-2 inhibition in AML. Supplementary Fig. S5. Kaplan-Meier Curve for AML patients. Supplementary Fig. S6. Uncropped Western blot membranes. Supplementary Table S1. 1H-NMR metabolite assignments. Supplementary Table S2. List of primers used for measurements of gene expression levels and mtDNA content by quantitative Real-Time PCR.