Supplemental Information on model formulation, data analysis and experimental evidence from Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation

The supplemental information includes detailed descriptions about the mathematical models for the core AMPK:HIF-1:ROS circuit, the regulation of metabolism by MYC, c-SRC and RAS and the evaluation of different metabolic therapeutic strategies, all the parameters used in the modeling and the parameter sensitivity analysis, detailed procedures to generate the AMPK and HIF-1 signatures and to quantify the activity of MYC, c-SRC and AKT and the experimental evidence on the core AMPK:HIF-1:ROS regulatory circuit and different metabolic therapies.