Supplemental Figure 1 - 12 from The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module

Supplemental Figure 1. Quantitation and statistical evaluation of the microarray data for Fig. 1A and Fig. 2H, I. Supplemental Figure 2. Somatic excision of Dach1 in prostate epithelial cells. Supplemental Figure 3. Transgenic deletion of Dach1 in the prostate epithelial cells enhances cellular proliferation and reduces cellular apoptosis. Supplemental Figure 4. Prostate specific expression of Dach1 enhances cyclin D1 and cyclin A1. Supplemental Figure 5. Quantitation and statistical evaluation of the microarray data for Fig. 3F and Fig. 4A, B. Supplemental Figure 6. ChIP analysis of cyclin A2 and cyclin E1 promoter regions. Supplemental Figure 7. Endogenous Dach1 is a key restraint of prostate cytokine production. Supplemental Figure 8. Time lapse microscopy of Dach1-/- vs. Dach1+/+ anterior prostate epithelial cells. Supplemental Figure 9. Transgenic deletion of Dach1 in prostate epithelial cells increases IL-6 and IL-8 expression.Supplemental Figure 10. Time lapse microscopy of Dach1+/+ or Dach1-/- ventral prostate epithelial cells. Supplemental Figure 11. The Expression of DACH1 in PC3 cells. Supplemental Figure 12. The relationship between DACH1 and IL-6, IL-8 in metastatic prostate cancer.