Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells.

Phanchanit Jindarojanakul,Yukiho Kobayashi,Hiroyuki Kamimoto,Yuki Niki, Aye Chan Myo,Sirichom Satrawaha,Keiji Moriyama

European journal of orthodontics（2023）

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摘要

SOD3 plays a role in periodontal tissue remodelling during OTM and in hypoxia-exposed PDL cells through ROS, HIF-1α, and RANKL/OPG pathways. Moreover, SOD3 treatment could attenuate the negative effects of hypoxia on the PDL cells.

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