Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19

Raquel Duque Nascimento Arifa,Marcela Helena Gonçalves-Pereira,Luciana Santiago,Cecilia Gómez Ravetti,Paula Frizera Vassallo, Fernanda de Fátima Souza Oliveira,Adriano de Paula Sabino,Mauro Martins Teixeira,Vandack Nobre,Helton da Costa Santiago,Daniele G. Souza

Inflammation research : official journal of the European Histamine Research Society ... [et al.]（2023）

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摘要

The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary environment during COVID -19 severity is not clear. Here, we found a decrease in the neutrophil count in BAL (bronchoalveolar lavage) in non-survivors and in older patients (> 60 years). In addition, we have shown that older patients have higher serum concentration of CXCL8 and increased IL-10 expression by neutrophils.

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关键词

Severe COVID-19,Neutrophils,ARDS,Elderly patients,Mechanical ventilation

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