Akebia saponin D acts via the PPAR-gamma pathway to reprogramme a pro-neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress.

Jinqiang Zhang,Qin Liu,Dapeng Su,Liangyuan Li,Chenghong Xiao,Hui He,Zili You,Tao Zhou

CNS neuroscience & therapeutics（2023）

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摘要

These results suggested that ASD acts via the PPAR-γ pathway to induce a pro-neurogenic microglia in dentate gyrus of CMS mice that can increase BDNF expression and promote NSPC proliferation, survival, and neurogenesis.

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关键词

BDNF-TrkB,akebia saponin D,major depressive disorder,microglia,neurogenesis,peroxisome proliferator-activated receptor-γ

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