Interactions of SNPs in Folate Metabolism Related Genes on Prostate Cancer Aggressiveness in European Americans and African Americans.

Hui-Yi Lin,Susan E Steck, Indrani Sarkar,Elizabeth T H Fontham,Alan Diekman,Lora J Rogers, Calvin T Ratliff,Jeannette T Bensen,James L Mohler,L Joseph Su

Cancers（2023）

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摘要

These SNP-SNP interactions in the folate metabolism-related genes have a larger impact than SNP individual effects on tumor aggressiveness for EA and AA PCa patients. These findings can provide valuable information for potential biological mechanisms of PCa aggressiveness.

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关键词

SNP,aggressiveness,folate metabolism,genetic variants,interaction,prostate cancer

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