SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.

Theodoros Karampitsakos,Apostolos Galaris,Ilianna Barbayianni,Giuseppe DeIuliis,Farida Ahangari,Fotis Sampsonas,Vasilina Sotiropoulou,Vassilis Aidinis,Anton M Bennett,Jose D Herazo-Maya, Nikolaos Xylourgidis,Petros Bakakos,Demosthenes Bouros,Naftali Kaminski,Argyrios Tzouvelekis

Diagnostics (Basel, Switzerland)（2023）

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摘要

SHP2 attenuates fibrotic responses in fibroblast cell lines through negative regulation of mitochondrial metabolism and induction of autophagy. SHP2 activation may represent a promising therapeutic strategy for patients with fibrotic lung diseases.

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关键词

SHP2,fibroblast,mammalian target of rapamycin complex-1,mitochondrial metabolism

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