Role of histone variant H2A.J in fine-tuning chromatin organization for the establishment of ionizing radiation-induced senescence

Mutaz A. Abd Al-Razaq,Benjamin M. Freyter,Anna Isermann,Gargi Tewary,Adele Mangelinck,Carl Mann,Claudia E. Ruebe

Cells（2023）

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摘要

The fine-tuned incorporation of H2A.J defines the epigenetic landscape for driving the senescence programme in response to radiation-induced DNA damage. Deregulated H2A.J deposition affects chromatin remodeling, transcription factor recruitment, and the pro-inflammatory secretome. Our findings provide new mechanistic insights into DNA-damage triggered epigenetic mechanisms governing the biological processes of radiation-induced injury.

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关键词

DNA-Segments with Chromatin Alterations Reinforcing Senescence (DNA-SCARS),Senescence-Associated Heterochromatin Foci (SAHF),Senescence-Associated Secretory Phenotype (SASP),histone variant H2A.J,ionizing radiation,radiation-induced senescence

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