Tissue and Serum Biomarkers in Degenerative Aortic Stenosis-Insights into Pathogenesis, Prevention and Therapy.

Alkistis Kapelouzou,Styliani Geronikolou,Irene Lidoriki,Christos Kontogiannis,Loukas Kaklamanis,Loukas Tsourelis,Dennis V Cokkinos

Biology（2023）

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摘要

We showed that six widely prevalent biomarkers affecting the atherosclerotic process were also involved in DAS, suggesting a strong osteogenic and pro-inflammatory profile, indicating that aortic valve calcification is a multifactorial biological process.

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关键词

HMGB-1,IL-18,PCSK9,biomarkers,degenerative aortic valve stenosis,irisin,osteoglycin,periostin,valvular heart disease

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