Identification of distinct tumor cell patterns with single-cell RNA sequencing integrating primary lung adenocarcinoma and brain metastasis tumor

Xi Wang,Dainan Zhang,Xiudong Guan,Shunchang Ma,Wenjianlong Zhou,Jiayi Peng,Linhao Yuan,Yangyang Wang,Shucheng Jin,Qin Xu,Deling Li,Shengtian Wu,Guijun Jia,Chuanbao Zhang,Wang Jia

Translational lung cancer research（2023）

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摘要

scRNA profiling that integrates LUAD BM and primary LUAD can provide information on those malignant cells with BM potential, offering additional prognostic information at cellular level, and may serve as a foundational resource for further tumor cell dissection and therapeutic target exploration.

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关键词

Single-cell RNA-sequencing (scRNA-seq),brain metastasis (BM),lung adenocarcinoma (LUAD),malignant

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