Efficacy of different platforms in detecting EGFR mutations using cerebrospinal fluid cell‐free DNA from non‐small ‐cell lung cancer patients with leptomeningeal metastases

Chi‐Lu Chiang,Hsiang‐Ling Ho,Yi‐Chen Yeh,Cheng‐Chia Lee,Hsu‐Ching Huang,Chia‐I Shen,Yung‐Hung Luo,Yuh‐Min Chen,Chao‐Hua Chiu,Teh‐Ying Chou

Thoracic Cancer（2023）

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摘要

The cobas EGFR Mutation Test, ddPCR, and NGS appear to be feasible methods for analyzing CSF ctDNA in patients with NSCLC and LM. In addition, NGS may provide comprehensive information regarding the mechanisms underlying osimertinib resistance.

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关键词

cell-free DNA,cerebrospinal fluid,epidermal growth factor receptor,next-generation sequencing,non-small-cell lung cancer

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