Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia.

Jacob Mathias Bech,Thilde Terkelsen,Annette Snejbjerg Bartels,Fabian Coscia,Sophia Doll,Siqi Zhao,Zhaojun Zhang,Nils Brünner,Jan Lindebjerg,Gunvor Iben Madsen,Xiangdong Fang,Matthias Mann,José Manuel Afonso Moreira

Gastroenterology（2023）

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摘要

We performed an in-depth analysis of quantitative proteomic data from 98 resected adenoma samples using various novel algorithms and statistical packages and found that their proteome can predict development of metachronous advanced lesions and progression several years in advance.

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Biomarkers,Colonic Adenomatous Polyps,Colorectal Cancer,Progression

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