Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis.

Daniel J Panyard,Yuetiva K Deming,Burcu F Darst,Carol A Van Hulle,Henrik Zetterberg,Kaj Blennow,Gwendlyn Kollmorgen,Ivonne Suridjan,Cynthia M Carlsson,Sterling C Johnson,Sanjay Asthana,Corinne D Engelman,Qiongshi Lu

Journal of Alzheimer's disease : JAD（2023）

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摘要

These findings provide further evidence of the role of the liver-functional genome in AD and the benefits of incorporating functional annotation into genomic research.

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关键词

Alzheimer’s disease,cerebrospinal fluid biomarkers,functional annotation,liver,polygenic risk score

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