Deletion of LCMR1 in alveolar type II cells induces lethal impairment of lung structure and function in adult mice

Journal of thoracic disease(2023)

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摘要
We successfully generated an AT2 cell-specific conditional knockout mouse model and further revealed the crucial role of in maintaining AT2 cell homeostasis.
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关键词
CRISPR/Cas9,Lung cancer metastasis-related protein 1 (LCMR1),alveolar type II cell,conditional gene knockout
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