ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.

Xiang Qu,Junjun Li,Li Liu,Jingbo Zhang,Ying Hua,Kota Suzuki,Akima Harada,Masako Ishida,Noriko Yoshida,Daisuke Okuzaki,Yoshiki Sakai,Yoshiki Sawa,Shigeru Miyagawa

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation（2023）

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摘要

Slow-release ONO-1301 scaffold provided an efficient delivery method for thick hiPSC-CM tissue. ONO-1301 promotes angiogenesis between the host and graft and improves nutritional and oxygen supply, thereby enhancing the survival of transplanted cells, effectively improving ejection fraction, and therapeutic effects.

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关键词

ONO-1301,angiogenesis,cardiac function,cardiomyocytes,hiPSCs

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