The combination of oxaliplatin and anti-PD-1 inhibitor promotes immune cells infiltration and enhances anti-tumor effect of PD-1 blockade in bladder cancer.

Zihan Zhao,Siyang Liu,Rui Sun,Wenjie Zhu,Yulin Zhang,Tianyao Liu,Tianhang Li, Ning Jiang,Hongqian Guo,Rong Yang

Frontiers in immunology（2023）

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摘要

OXP could increase the infiltration of immune cells in TIME to promote the anti-tumor activity of anti-PD-1 inhibitor. The present research provided an appropriate rationale of combination chemotherapy and immunotherapy therapy for BLCA.

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关键词

bladder cancer,combination therapy,immune checkpoint inhibitors,immunotherapy,oxaliplatin,tumor immune microenvironment

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