Fusobacterium nucleatum induces a tumor microenvironment with diminished adaptive immunity against colorectal cancers.

Han Sang Kim,Chang Gon Kim,Won Kyu Kim,Kyung-A Kim,Jinseon Yoo,Byung Soh Min,Soonmyung Paik,Sang Joon Shin,Hyukmin Lee,Kyungwon Lee,Hoguen Kim,Eui-Cheol Shin,Tae-Min Kim,Joong Bae Ahn

Frontiers in cellular and infection microbiology（2023）

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摘要

FN enhanced the suppressive immune microenvironment with high depletion of CD8 T cells and enrichment of FoxP3 regulatory T cells in human colorectal cancer cases. Our findings suggest a potential association for FN in adaptive immunity, with biological and prognostic implications.

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关键词

Fusobacterium nucleatum,T cells,anti-tumor immune response,colorectal cancer,gut microbiota

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