Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus.

Yong Yang,Zihan Han,Zhaoya Gao,Jiajia Chen,Can Song,Jingxuan Xu,Hanyang Wang,An Huang,Jingyi Shi,Jin Gu

Chinese medical journal（2023）

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摘要

Unique fecal microbiome signatures exist in CRC patients with T2DM compared to those with non-diabetic CRC. Alterations in GM composition and SCFAs and secondary BAs levels may promote CRC development.

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关键词

Bile acids,Colorectal cancer,Gut microbiota,Short-chain fatty acids,Type 2 diabetes mellitus

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