Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification.

Nikolaos T Skenteris, Esmeralda Hemme, Lucie Delfos,Glykeria Karadimou,Eva Karlöf,Mariette Lengquist,Malin Kronqvist,Xiang Zhang,Lars Maegdefessel,Leon J Schurgers,Hildur Arnardottir,Erik A L Biessen,Ilze Bot,Ljubica Matic

Vascular pharmacology（2023）

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摘要

Integrative analyses from human plaques showed that MC activation is inversely associated with macrocalcification and positively with parameters of plaque vulnerability. Mechanistically, MCs induce SMC osteogenic reprograming, while matrix calcification in turn attenuates MC activation, offering new therapeutic avenues for exploration.

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关键词

Atherosclerotic plaques,Biobank of Karolinska endarterectomy (BiKE),Intimal calcification,Mast cells,Smooth muscle cells

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