Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study.

Julie E Mangino,Michael S Firstenberg, Rita K C Milewski,William Rhys-Williams, James P Lees,Aaron Dane,William G Love, Jesus Gonzalez Moreno

Infection control and hospital epidemiology（2023）

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摘要

We studied 83 cardiac-surgery patients with nasal carriage who received 4 intranasal administrations of XF-73 nasal gel or placebo <24 hours before surgery. One hour before surgery, patients exhibited a nasal carriage reduction of 2.5 log with XF-73 compared to 0.4 log CFU/mL for those who received placebo (95% CI, -2.7 to -1.5; < .0001).

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关键词

nasal gel,cardiac surgery patients,nasal carriage,efficacy results,placebo-controlled

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