Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Variants with suggestive associations with AAO were associated with biological processes including clusterin, heparin sulfate, and amyloid processing. The detection of these effects in the presence of a strong mutation for ADAD reinforces their potentially impactful role.

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AAO,ACE,AOO,Alzheimer,CLU,E280A,HS3ST1,HSPG2,LRP1B,PSEN1,SIAH3,TSPAN10,TSPAN14,ZC3H13,age of onset,amyloid,clusterin,heparin sulfate,tetraspanin

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