Preferential Hematopoietic Differentiation in Induced Pluripotent Stem Cells Derived From Human Umbilical Cord Arterial Endothelial Cells.

Arteriosclerosis, thrombosis, and vascular biology(2023)

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摘要
Collectively, our data suggest that somatic cell memory may predispose HuA-iPSCs to differentiate more amenably into hematopoietic fate, bringing us closer to generating hematopoietic cell types in vitro from nonhematopoietic tissue for therapeutic applications.
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关键词
cell differentiation,endothelial cells,hematopoietic stem cells,induced pluripotent stem cells
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