Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study.

Dominic Fenn,Thijs A Lilien,Laura A Hagens,Marry R Smit,Nanon F L Heijnen,Anita M Tuip-de Boer,Anne H Neerincx,Korneliusz Golebski,Dennis C J J Bergmans,Ronny M Schnabel,Marcus J Schultz,Anke H Maitland-van der Zee,Paul Brinkman,Lieuwe D J Bos

ERJ open research（2023）

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摘要

Despite a comprehensive translational approach, validation of known and novel volatile biomarkers of oxidative stress was not possible in patients at risk of pulmonary oxidative injury. The inconsistencies observed highlight the difficulties faced in VOC biomarker validation, and that caution is warranted in the interpretation of the pathophysiological origin of discovered exhaled breath biomarkers.

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