Ancestral, Pregnancy, and Negative Early Life Risks Shape Children's Brain Dis/Similarity to Schizophrenia.

Peter Kochunov,Yizhou Ma,Kathryn S Hatch,Si Gao,Ashley Acheson,Neda Jahanshad,Paul M Thompson,Bhim M Adhikari,Heather Bruce,Andrew Van der Vaart,Joshua Chiappelli,Xiaoming Du,Aris Sotiras,Mark D Kvarta,Tianzhou Ma,Shuo Chen,L Elliot Hong

Biological psychiatry（2023）

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摘要

In summary, in a cohort where most children will not develop SSD, familial, pre and perinatal, and early developmental risks can alter brain patterns in the direction observed in adult SSD patients. Individual similarity to adult SSD patterns may provide an early biomarker of the effects of genetic and developmental risks on the brain prior to psychotic or prodromal symptom onset.

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关键词

Adolescence,big data,brain development,imaging,individual prediction,schizophrenia

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