Adverse effect of PNPLA3 p.I148M genetic variant on kidney function in middle-aged individuals with metabolic dysfunction.

Alessandro Mantovani,Serena Pelusi,Sara Margarita,Francesco Malvestiti,Michela Dell'Alma,Cristiana Bianco,Luisa Ronzoni,Daniele Prati,Giovanni Targher,Luca Valenti

Alimentary pharmacology & therapeutics（2023）

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摘要

We found a detrimental impact of the PNPLA3 p.I148M variant on eGFR levels in middle-aged individuals with metabolic dysfunction. This association was independent of established risk factors, ethnicity and genetic predisposition to CKD. PNPLA3 p.I148M silencing may protect against kidney damage progression in carriers.

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genetics,glomerular filtration rate,nonalcoholic fatty liver disease,nonalcoholic steatohepatitis,polygenic risk score,precision medicine

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