Is There an Inflammatory Profile of Perinatal Depression?
Current psychiatry reports(2023)
摘要
Purpose of Review To synthesize and critically examine recent evidence regarding associations between immune system activity and perinatal depression. Recent Findings Despite a significant number of studies assessing potential immunological markers of perinatal depression, it does not appear that levels of any individual pro- or anti-inflammatory marker is a useful predictor of perinatal depression. Some recent studies have observed differences in overall immune system functioning and adaptation across this period, taking into account multiple pro- and anti- inflammatory markers. Furthermore, there is evidence for interactions between depression and maternal psychosocial factors. Immune system functioning may be a mechanism through which social determinants of health contribute to risk for perinatal depression. Summary There is substantial evidence implicating dysregulated immune activity in perinatal depression, yet little clarity regarding a consistent immune profile, especially based on analysis of circulating peripheral cytokines.
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关键词
Depression,Immune,Inflammation,Postnatal depression,Pregnancy
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