Combi-TED: a new trial testing Tedopi((R)) with docetaxel or nivolumab in metastatic non-small-cell lung cancer progressing after first line

Patients with lung cancer that has spread to other parts of the body are usually treated with a combination of chemotherapy and drugs that stimulate the immune system to kill cancer cells, which is referred to as immunotherapy. If after receiving these drugs the cancer still gets worse, patients have only few treatment options left and are usually treated with chemotherapy only. Researchers will study if a new medicine called Tedopi((R)), a vaccine that attacks specifically cancer cells, used together with chemotherapy or immunotherapy, will work better then chemotherapy alone for these patients. The study will monitor how long patients will live after treatment, for how long they will live without their disease getting worse and how many patients will improve after treatment. Moreover, researchers will study if patients present specific features, such as certain molecules in their tumor cells or blood cells, that may indicate that they respond better to certain treatments.