Characterization of the immune impairment of patients with tuberculosis and COVID-19 coinfection.

Saeid Najafi-Fard,Alessandra Aiello,Assunta Navarra,Gilda Cuzzi,Valentina Vanini,Giovanni Battista Migliori,Gina Gualano,Carlotta Cerva,Alba Grifoni,Alessandro Sette,Francesco Vaia,Fabrizio Palmieri,Delia Goletti

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2023）

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摘要

We found immune signatures associated with TB-COVID-19 coinfection and observed a major impairment of SARS-CoV-2-specific and, to a lesser extent, the Mtb-specific immune responses. These findings further advance our knowledge of the immunopathology of TB-COVID-19 coinfection.

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关键词

COVID-19,Coinfection,Immune response,M. tuberculosis,SARS-CoV-2,Tuberculosis

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