Atorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial.

Azita Hajhossein Talasaz,Parham Sadeghipour,Hooman Bakhshandeh,Babak Sharif-Kashani,Farid Rashidi,Mohammad Taghi Beigmohammadi,Keivan Gohari Moghadam,Somayeh Rezaian,Ali Dabbagh,Seyed Hashem Sezavar,Mohsen Farrokhpour,Atefeh Abedini,Rasoul Aliannejad,Taghi Riahi,Mahdi Yadollahzadeh,Somayeh Lookzadeh,Parisa Rezaeifar,Samira Matin,Ooria Tahamtan,Keyhan Mohammadi,Elnaz Zoghi,Hamid Rahmani,Seyed Hossein Hosseini,Seyed Masoud Mousavian,Homa Abri,Pardis Sadeghipour,Elahe Baghizadeh,Farnaz Rafiee,Sepehr Jamalkhani,Ahmad Amin,Bahram Mohebbi,Seyed Ehsan Parhizgar,Mahshid Soleimanzadeh,Maryam Aghakouchakzadeh,Vahid Eslami,Pooya Payandemehr,Hossein Khalili,Hamed Talakoob,Taranom Tojari,Shadi Shafaghi,Sanaz Tabrizi,Hessam Kakavand,Alireza Kashefizadeh,Atabak Najafi,David Jiménez,Aakriti Gupta,Mahesh V Madhavan,Sanjum Sethi,Sahil A Parikh,Manuel Monreal,Naser Hadavand,Alireza Hajighasemi,Khalil Ansarin,Majid Maleki,Saeed Sadeghian,Stefano Barco,Bob Siegerink,Erica Spatz,Gregory Piazza,Ajay J Kirtane,Benjamin W Van Tassell,Gregory Yh Lip, Erik Klok,Samuel Z Goldhaber,Gregg Stone,Harlan Krumholz,Behnood Bikdeli

Thrombosis and haemostasis（2023）

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摘要

Atorvastatin 20 mg compared with placebo did not significantly reduce the 90-day composite of death, treatment with ECMO, or venous/arterial thrombosis. However, the point estimates do not exclude a potential clinically meaningful treatment effect, especially among patients who presented within 7 days of symptom onset. (NCT04486508).

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关键词

statin, atorvastatin, lipid, COVID-19, functional limitations

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