Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease.

Zixi Wang,Shijia Zhu,Yuemeng Jia,Yunguan Wang,Naoto Kubota,Naoto Fujiwara, Ruth Gordillo,Cheryl Lewis,Min Zhu,Tripti Sharma,Lin Li,Qiyu Zeng,Yu-Hsuan Lin,Meng-Hsiung Hsieh,Purva Gopal,Tao Wang,Matt Hoare,Peter Campbell,Yujin Hoshida,Hao Zhu

bioRxiv : the preprint server for biology（2023）

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摘要

Mosaic mutations that increase lipotoxicity lead to clonal disappearance in NASH. In vivo screening can identify genes that alter hepatocyte fitness in NASH. Mosaic mutations are positively selected due to reduced lipogenesis. In vivo screening of transcription factors and epifactors identified new therapeutic targets in NASH.

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关键词

adaptive pathways,liver,metabolic,clones

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