Formaldehyde aggravates allergic contact dermatitis by facilitating NLRP3 inflammasome activation in macrophages

Huijuan Ma,Qi Shu, Zhiming Li,Xiaodong Song,Huan Xu

International Immunopharmacology（2023）

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摘要

•0.05% Formaldehyde aggravated allergic contact dermatitis induced by 2,4-dinitro-1-fluorobenzene.•Formaldehyde potentiated the activation of NLRP3 inflammasome in macrophages.•Formaldehyde-promoted NLRP3 inflammasome activation was alleviated by NLRP3 inhibition.•NLRP3 inhibition attenuated formaldehyde-aggravated allergic contact dermatitis.

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关键词

NLRP3 inflammasome,Formaldehyde immunotoxicity,Allergic contact dermatitis,Inflammatory cytokines,Caspase-1,Macrophages

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