Salivary levels of disease-related biomarkers in the early stages of Parkinson's and Alzheimer's disease: A cross-sectional study .

Masoomeh Sabaei,Saba Rahimian,Arsh Haj Mohamad Ebrahim Ketabforoush,Homa Rasoolijazi,Babak Zamani, Fahime Hajiakhoundi,Mansoureh Soleimani,Gholamali Shahidi, Mahmood Faramarzi

IBRO neuroscience reports（2023）

引用 3|浏览10

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摘要

Evaluation of p-tau, α-syn, and Aβ 1-42 levels in the saliva of AD and PD patients could help the early diagnosis. The p-tau level might be valuable for differentiation between AD and PD. Therefore, these hopeful investigations could be done to reduce the usage of invasive diagnostic methods, which alone is a success in alleviating the suffering of AD and PD patients. Moreover, introducing accurate salivary biomarkers according to the pathophysiology of AD and PD should be encouraged.

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关键词

AD, Alzheimer's disease,Alzheimer's disease,Aβ, ‏‎ Beta-amyloid 1–42,BDRS, Blessed Dementia Rating Scale,Beta-amyloid,CSF, Cerebrospinal fluid,CT scan, Computed tomography scan,ELISA, Enzyme-linked immunosorbent assay,MDS-UPDRS, MDS-Unified Parkinson’s Disease Rating Scale,MMSE, MCI (mild cognitive impairment mini-mental state examination,MRI, Magnetic resonance imaging,MoCA, Montreal Cognitive Assessment,NFTs, Neurofibrillary Tangles,NIA-AA, National Institute on Aging-Alzheimer’s Association,PD, Parkinson's disease,Parkinson's disease,Phosphorylated tau,ROC, Receiver operating characteristic,Total alpha-synuclein,p-tau, Phosphorylated tau,α-syn, Total alpha-synuclein

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