Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Jamie L Todd,Jeremy M Weber,Francine L Kelly,Megan L Neely, Andrew Nagler,Dylan Carmack,Courtney W Frankel,David M Brass,John A Belperio,Marie M Budev,Matthew G Hartwig,Tereza Martinu,John M Reynolds,Pali D Shah,Lianne G Singer,Laurie D Snyder,S Sam Weigt,Scott M Palmer

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation（2023）

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摘要

We discovered a threshold for reduced BALF CCSP to discriminate future CLAD risk; supporting the utility of BALF CCSP as a tool for early posttransplant risk stratification. Additionally, our finding that low CCSP associates with future CLAD underscores a role for club cell injury in CLAD pathobiology.

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关键词

CLAD risk,bronchoalveolar lavage fluid,chronic lung allograft dysfunction,club cell secretory protein,lung transplantation

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