Development of an equilibrium dialysis ID-UPLC-MS/MS candidate reference measurement procedure for free thyroxine in human serum.

Ashley Ribera,Li Zhang, Amonae Dabbs-Brown,Otoe Sugahara, Krista Poynter,Katleen van Uytfanghe, Eri Shimizu,Antonius E van Herwaarden,Julianne C Botelho,Uliana Danilenko,Hubert W Vesper

Clinical biochemistry（2023）

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摘要

Our ED-LC-MS/MS cRMP provides high accuracy, precision, specificity, and sensitivity for FT4 measurement. The cRMP can serve as a higher-order standard for establishing measurement traceability and provide an accuracy base for the standardization of FT4 assays.

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关键词

Equilibrium dialysis,FT4,Free thyroxine,Interlaboratory comparison,LC-MS/MS,Reference Measurement Procedure

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