No NFATC2 fusion in simple bone cyst of the jaw.

Sheena L M Ong,Isadora P Gomes,Hans J Baelde,Fabricio Passador-Santos,Bruno A B de Andrade,Inge H Briaire-de Bruijn,Israel L Cavalcante,Willem H Schreuder,Anne-Marie Cleton-Jansen,Arjen H G Cleven,Karoly Szuhai,Carolina C Gomes,Judith V M G Bovée

Histopathology（2023）

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摘要

In our study, NFATC2 rearrangement is absent in solitary jaw SBC (n = 7) and COD-associated SBC (n = 2). Our findings suggest that SBC presenting in the jaw is molecularly different from SBC in long bones. Future molecular studies may confirm the absence of clonal molecular aberrations in SBC of the jaw which would support a non-neoplastic, reactive origin.

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关键词

NFATC2,bone tumour,cemento-osseous dysplasia,gene fusion,jaw,simple bone cyst

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