Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti-PDL1 efficacy in head and neck cancer.

Kourtney L Kostecki,Mari Iida, Anne L Wiley,Stanley Kimani,Bridget Mehall,Kaitlin Tetreault,Roxana Alexandridis,Menggang Yu,Seungpyo Hong,Ravi Salgia,Justine Y Bruce,Raymond B Birge,Paul M Harari,Deric L Wheeler

Head & neck（2023）

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摘要

This data indicates that simultaneous targeting of Axl and MerTK with INCB081776, either alone or in combination with anti-PDL1, slows tumor growth and creates a proinflammatory TIME in mouse models of HNC.

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关键词

Axl,MerTK,PDL1,head and neck cancer,tumor microenvironment

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