Cytokines and Immune Cell Phenotype in Acute Kidney Injury Associated With Immune Checkpoint Inhibitors

Naba Farooqui,Mark Zaidi,Lisa Vaughan,Trevor D McKee, Eram Ahsan,Kevin D Pavelko,Jose C Villasboas,Svetomir Markovic,Timucin Taner,Nelson Leung,Haidong Dong,Mariam P Alexander,Sandra M Herrmann

Kidney International Reports（2023）

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摘要

These results suggest that specific T-cell responses and their respective cytokines may be indicative of AKI associated with ICI therapy and may help to differentiate AKI-ICI from AKI-other. Urine TNF-α is a promising biomarker for AKI-ICI, which is most often caused by acute interstitial nephritis (AIN), and TNF-α pathway may serve as a potential target for therapeutic intervention.

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关键词

acute interstitial nephritis,acute kidney injury,biomarkers,cytokines,immune cell phenotyping,immune checkpoint inhibitors

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