The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer's disease.

Yanna Tian,Katie Anne Fopiano,Vadym Buncha,Liwei Lang,Hayden A Suggs,Rongrong Wang,R Daniel Rudic,Jessica A Filosa,Zsolt Bagi

Frontiers in molecular neuroscience（2023）

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摘要

Thus, we propose that a reduced ADAM17 expression in cerebral microvessels impairs vasodilator function, which may contribute to the development of cognitive dysfunction in APP/PS1 mice, and that ADAM17 can potentially be targeted for therapeutic intervention in AD.

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关键词

Alzheimer’s disease,a disintegrin and metalloproteinase 17,cognitive decline,mouse model,vasodilation

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