Meteorin-like levels are associated with active brown adipose tissue in early infancy.

Cristina Garcia-Beltran, Artur Navarro-Gascon,Abel López-Bermejo,Tania Quesada-López,Francis de Zegher,Lourdes Ibáñez,Francesc Villarroya

Frontiers in endocrinology（2023）

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摘要

Circulating METRNL levels are high in the first year of life and correlate with indices of BAT activity and with levels of an established brown adipokine such as CXCL14. These data, in addition with the high expression of in neonatal BAT and in thermogenically-stimulated brown/beige adipocytes, suggest that METRNL is actively secreted by BAT and may be a circulating biomarker of BAT activity in early life.

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关键词

brown adipokine,brown adipose tissue (BAT),infancy,meteorin-like (METRNL),thermogenesis

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