Hypoxia-induced degradation of PICK1 by RBCK1 promotes the proliferation of nasopharyngeal carcinoma cells.

Yingzi Zhang,Yue Lu,Yiqing Xu,Ziyu Le,Yi Liu,Wenzhi Tu,Yong Liu

Life sciences（2023）

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摘要

These data provide evidence for an NPC cell adaptation mechanism to hypoxia, where HIF-1α regulates RBCK1, which targets PICK1 for degradation to promote cell proliferation.

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关键词

HIF-1α,Hypoxia,Nasopharyngeal carcinoma,PICK1,RBCK1

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