Validation of prediction models for radiation-induced late rectal bleeding: Evidence from a large pooled population of prostate cancer patients.

Alessandro Cicchetti,Claudio Fiorino,Martin A Ebert,Jacopo Iacovacci,Angel Kennedy,David J Joseph, James W Denham,Vittorio Vavassori,Gianni Fellin,Cesare Cozzarini,Claudio Degli Esposti,Pietro Gabriele,Fernando Munoz,Barbara Avuzzi,Riccardo Valdagni,Tiziana Rancati

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology（2023）

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摘要

Five published NTCP models developed on non-contemporary cohorts were able to predict a relative increase in the toxicity response in a more recent validation population. Compared to QUANTEC findings, dosimetric results pointed toward mid-high doses of rectal DVH. The external validation cohort confirmed abdominal surgery and cardiovascular diseases as risk factors.

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关键词

Late rectal bleeding,Model validation,Multivariable models,NTCP models,Prostate cancer

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