Which trial do we need? Rational therapeutic management of periprosthetic joint infection.

Periprosthetic joint infection (PJI) is a feared complication after joint replacement. Because of the high susceptibility of an implant to infection, the risk of PJI cannot be completely eliminated. Indeed, despite considerable efforts for prevention, the incidence of PJI did not significantly change between 2005 and 2015 [ [1] Kurtz S.M. Lau E.C. Son M.S. Chang E.T. Zimmerli W. Parvizi J. Are we winning or losing the battle with periprosthetic joint infection: trends in periprosthetic joint infection and mortality risk for the Medicare Population. J Arthroplasty. 2018; 33: 3238-3245https://doi.org/10.1016/j.arth.2018.05.042 Abstract Full Text Full Text PDF PubMed Scopus (189) Google Scholar ]. Considering the availability of different treatment options, selecting the least invasive for each patient without compromising the cure rate is important.