ROS, pH, and magnetically responsive ZnFe2O4@l-Cysteine@NGQDs nanocarriers as charge-reversal drug delivery system for controlled and targeted cancer chemo-sonodynamic therapy

Faezeh Gandomi,Mojtaba Rostami,Farhad Ahmadi,Amir Mohammad Sorouri,Alireza Badiei,Mahdi Fasihi-Ramandi,Mohammad Reza Ganjali,Hermann Ehrlich,Mehdi Rahimi-Nasrabadi

Inorganic Chemistry Communications（2023）

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摘要

•Zeta potential results showed the pH-responsive charge-reversal drug delivery system.•MTT results presented ZnFe2O4@l-Cysteine@NGQDs is a non-toxic carrier.•ZnFe2O4@l-Cysteine@NGQDs have great potential in chemo-sonodynamic therapy.•CSDT-based combination therapies show good synergistic effects.•Ultrasound-triggered controlled release of ZnFe2O4@l-Cysteine@NGQDs nano-carriers was demonstrated for 96 h.

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关键词

Ultrasound,Nano-sonosensitizers,Chemo-sonodynamic therapy,l-Cysteine,Curcumin

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