Healthcare systems data in the context of clinical trials - A comparison of cardiovascular data from a clinical trial dataset with routinely collected data.

Archie Macnair,Matthew Nankivell,Macey L Murray,Stuart D Rosen, Sally Appleyard,Matthew R Sydes,Sylvia Forcat,Andrew Welland,Noel W Clarke,Stephen Mangar,Howard Kynaston,Roger Kockelbergh,Abdulla Al-Hasso,John Deighan,John Marshall,Mahesh Parmar,Ruth E Langley,Duncan C Gilbert

Contemporary clinical trials（2023）

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摘要

Concordance between datasets was lower than anticipated and the HSD used could not straightforwardly replace current trial practices, nor directly identify protocol-defined CVS events. Further work is required to improve the quality of HSD and consider event definitions when designing clinical trials incorporating HSD.

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关键词

Cardiovascular disease,Clinical trials,Healthcare systems data,Prostate cancer

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