Neuroinflammation and amyloid deposition in the progression of mixed Alzheimer and vascular dementia.

Chunwei Ying,Peter Kang,Michael M Binkley,Andria L Ford,Yasheng Chen,Jason Hassenstab,Qing Wang,Jeremy Strain,John C Morris,Jin-Moo Lee,Tammie L S Benzinger,Hongyu An

NeuroImage. Clinical（2023）

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摘要

Neuroinflammation and Aβ deposition may represent two distinct pathophysiological pathways, and both independently contributed to the progression of cognitive impairment in mixed AD and VCID pathologies. Neuroinflammation, but not Aβ deposition, contributed to WMH volume and progression.

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关键词

Alzheimer’s disease,Amyloid beta peptides,Neuroinflammation,Vascular contributions to cognitive impairment and dementia,White matter hyperintensities

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