An extended kinetic model-based correction factor equation to account hemodialysis post-treatment hemoconcentration.
The International journal of artificial organs(2023)
摘要
The hemoconcentration effect for middle weight solutes in hemodialysis is corrected by oversimplified methods based on hematocrit changes or distribution volume variations. Here we implemented a variable volume dual pool kinetic model targeted at obtaining a precise correction factor equation for extracellularly distributed solutes based on relevant kinetic parameters such as the ultrafiltration to dry weight ratio UF/DW, the dialyzer clearance, , the intercompartment mass-transfer coefficient, , and the central compartment to extracellular volume ratio, α. More than 300,000 solutions of the model were computed, performing a sweep among physiological values of the proposed kinetic parameters, resulting in a linear regression denoted by the expression = 1.0707 - 5.2246 (UF/DW) - 0.0005 - 0.0004 - 0.0007 α, with an excellent coefficient of determination = 0.983. The presented f provides a substantial extension of the currently implemented methods to estimate the hemoconcentration factor for middle and high molecular weight extracellular distributed solutes in hemodialysis.
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关键词
Correction factor,distribution volume,hemoconcentration,on-line hemodiafiltration,uremic toxins
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