Serpin B9 controls tumor cell killing by CAR T cells.

Thomas Kimman,Anne Slomp,Anne Martens,Sarah Grabherr,Shuang Li,Eline van Diest,Jan Meeldijk,Jurgen Kuball,Monique C Minnema,Eric Eldering,Niels Bovenschen,Zsolt Sebestyén,Victor Peperzak

Journal for immunotherapy of cancer（2023）

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摘要

Overall, the data indicate that serpin B9 is a resistance mediator for CAR T cell-mediated tumor cell killing that should be inhibited or bypassed to improve CAR T-cell responses.

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关键词

Cytotoxicity, Immunologic,Hematologic Neoplasms,Immunotherapy, Adoptive

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