Cobalt(II)-Catalyzed C(sp 3 )-C(sp 3 ) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-Glycosides from Glycals.

We report a ligand-controlled Co -catalyzed C(sp )-C(sp ) coupling hydroalkylation for direct and β-selective synthesis of 2-deoxy-C-glycosides from glycals. This reaction proceeds by a radical pathway for alkyl halide activation and is β-selective through ligand control. This approach may inspire the development of further stereoselective coupling reactions with potential application in the field of carbohydrates.