Association analysis of polymorphisms at GLRB , GRIA2 , and GASK1B genes with reproductive traits in Dazu Black Goats.

Xingqiang Fang, Songjian Yang, Meixi Chen,Ruifan Sun,Le Zhao,Bowen Gu,Jipan Zhang,Deli Huang, Taikang Zheng,Yuanping Zhao,Peng Peng,Yongju Zhao

Animal biotechnology(2023)

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摘要
Reproductive traits are essential economic traits in goats. This study aimed to analyze the relationship between single nucleotide polymorphisms (SNPs) within the genes of , , and , and reproductive traits (kidding traits and placental traits) in goats. We used the resequencing data of 150 Dazu Black Goats to perform correlation analysis with the average litter size. We screened thirteen SNPs loci in introns and then used the Sanger method to genotype the remaining 150 Dazu Black Goats. The results showed that a total of six SNPs were screened. Three SNPs related to litter size and live litter size (g.28985790T > G, g.28986352A > G, and g.28987976A > G); one SNP related to total cotyledon area (g.29203243G > A); two SNPs related to placental efficiency (g.30189055G > A and g.30193974C > T); one SNP associated with cotyledon support efficiency (g.30193974C > T). The qPCR results showed that , , and were all highly expressed in the udder, kidney, uterus, and ovary. It indicated that these three candidate genes might affect the reproductive traits, which could be used as candidate markers for reproductive traits in Dazu Black Goats. Moreover, association studies on a large scale are still needed to figure out what effect these SNPs have on reproductive traits.
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关键词
Dazu Black Goat,GASK1B gene,GLRB gene,GRIA2 gene,polymorphism,reproductive traits
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